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Does Rejuran Injection Affect Your Health?

Dr. Anh Thu, MD — Specialist Level II DermatologistAug 27, 20255 min read
Does Rejuran Injection Affect Your Health?

In recent years, Rejuran injections have become a popular beauty solution chosen by many customers thanks to their superior ability to restore and rejuvenate the skin. However, many people still wonder whether Rejuran injections have any impact on health. This article from Wedo Skin Clinic will help you understand clearly about Rejuran, its benefits, and the safety level of this treatment.

What is Rejuran?

Rejuran injection is an aesthetic treatment that uses Polynucleotide (PN) extracted from salmon, which has a high compatibility with human DNA. When introduced into the skin, PN helps regenerate cells, improve elasticity, and stimulate the natural production of collagen and elastin. This therapy has been researched and widely applied in South Korea, and is now highly regarded by dermatologists as a safe and effective solution for aging skin.

Rejuran is a micro-injection therapy containing polynucleotide (PN) derived from salmon DNA, which helps regenerate and restore the skin from within.

Rejuran is a micro-injection therapy containing polynucleotide (PN) extracted from salmon DNA, helping to regenerate and restore the skin from within
Rejuran is a micro-injection therapy containing polynucleotide (PN) extracted from salmon DNA, helping to regenerate and restore the skin from within

>>>>>> See more: Rejuran Healer – Comprehensive rejuvenation elixir from salmon DNA

Benefits of Rejuran Injections

Rejuran is not only a rejuvenation method but is also considered a skin-healing therapy thanks to its strong ability to restore and regenerate from deep within. After injection, Polynucleotide actively works on each cell, helping the skin quickly regain its health and youthfulness.

Repair and regenerate damaged skin: Thanks to PN extracted from salmon, Rejuran restores damaged skin caused by acne, scars, or cosmetic procedures such as laser and chemical peels. This action works deep inside the dermis, repairing and strengthening the skin from within.

Stimulate natural collagen and elastin production: Collagen and elastin are essential components that determine skin elasticity and firmness. Rejuran promotes their natural production, helping to improve sagging skin and restore smoothness and tightness.

Reduce fine lines and wrinkles: With strong cell regeneration ability, Rejuran fills in shallow wrinkles and significantly improves fine lines around the eyes, mouth, and forehead, making the skin smoother, younger, and fresher.

Improve pigmentation and brighten skin tone: Rejuran also helps improve dullness, even out skin tone, and bring natural radiance. It is particularly effective for those with uneven tone, dark spots, or post-acne marks.

Does Rejuran Injection Affect Health?

With its safe and biocompatible PN components, Rejuran injections generally do not negatively affect health if performed according to medical standards. However, like many other cosmetic procedures, some temporary side effects may occur, such as mild swelling, redness, or bruising at the injection site, which usually disappear after 1–2 days.

Rejuran does not cause serious health risks because PN from salmon DNA is safe and highly compatible with the human body.

Rejuran injections do not cause serious health effects because the PN component extracted from salmon DNA is safe and highly biocompatible with the human body
Rejuran injections do not cause serious health effects because the PN component extracted from salmon DNA is safe and highly biocompatible with the human body

Standard Rejuran Injection Procedure at Wedo

At Wedo Skin Clinic, Rejuran injections are always performed by dermatology specialists, strictly following medical protocols and ensuring absolute sterility. The process includes:

Step 1: Personalized consultation and examination

The dermatologist checks the skin condition, aging level, elasticity, and other issues such as scars or pigmentation. Based on this assessment, the doctor designs a personalized treatment plan, determines the number of sessions, and selects the injection areas.

Step 2: Skin cleansing and numbing

The skin is thoroughly cleansed with a specialized solution to remove dirt, oil, and bacteria. Then, a topical anesthetic is applied for 20–30 minutes to minimize discomfort.

Step 3: Precise Rejuran injection

Using an ultra-fine needle, the doctor injects Polynucleotide (PN) into the dermis layer. This requires high precision to ensure even distribution for maximum rejuvenation and healing effects.

Step 4: Post-injection care at the clinic

After treatment, soothing and recovery products are applied to calm the skin, reduce redness, and minimize swelling. The doctor also monitors the initial reaction to ensure safety.

Step 5: Home care and follow-up

Patients receive detailed instructions: avoid makeup for 24 hours, limit sun exposure, avoid steaming or exfoliation for several days, and always apply sunscreen and moisturizer. A follow-up visit is scheduled to evaluate results and plan further sessions if needed

Important Notes Before and After Rejuran Injections

To maximize effectiveness and safety, patients must not only choose a reputable clinic but also follow the correct pre- and post-treatment guidelines. Proper preparation reduces risks, while correct aftercare directly impacts recovery and results.

Before Rejuran injection:

  • Avoid alcohol and smoking for at least 3 days.
  • Stop taking aspirin or anticoagulants to minimize bruising and swelling.
  • Do not proceed if the skin is infected, allergic, or has open wounds.
  • Inform the doctor about any ongoing medication or allergy history.

After Rejuran injection:

  • Mild redness or swelling may occur for 1–2 days—this is normal.
  • Avoid makeup for 24 hours to reduce infection risk.
  • Do not steam, massage strongly, or exfoliate for 3–5 days.
  • Always protect skin with broad-spectrum sunscreen.
  • Maintain gentle skincare and hydrate well.
  • Follow the treatment schedule and doctor’s instructions strictly.
Important Notes Before and After Rejuran Injections
Important Notes Before and After Rejuran Injections

Conclusion

Rejuran injection is a safe and effective rejuvenation therapy that visibly improves aging and damaged skin, restoring health and radiance. When performed at a trusted clinic like Wedo Skin Clinic, patients can be assured of product quality, doctor expertise, and optimal results.

If you are seeking a comprehensive skin rejuvenation solution, consider Rejuran injections combined with advanced technologies like HIFU at Wedo to quickly regain firm, smooth, and radiant skin.

Frequently Asked Questions about Rejuran Injections

How long until Rejuran shows results?

Typically, skin improvements can be seen after 2–4 weeks, with the most noticeable effects after completing 3–4 sessions.

How long do the results last?

Results usually last from 9–12 months, depending on individual skin condition and care routine.

Does Rejuran injection hurt?

Only mild stinging is felt, but topical anesthesia is applied, so patients can feel at ease.

Who should consider Rejuran?

Those with early aging, fine lines, thin or weak skin, or those wanting to restore skin after damage such as laser or peel treatments.

What should be avoided after Rejuran injection?

Avoid sun exposure, makeup within 24 hours, steaming, massage, and harsh acid-based skincare until the skin has fully recovered.
Dr. Anh Thu, MD — Specialist Level II Dermatologist
Medically reviewed by

Dr. Anh Thu, MD — Specialist Level II Dermatologist

Reviewed:

Education & Professional Credentials

Dr. Anh Thu completed her entire formal and advanced clinical training at the University of Medicine and Pharmacy at Ho Chi Minh City (UMP HCMC), the top-tier medical institution in Southern Vietnam:

  • Doctor of Medicine (MD) – University of Medicine and Pharmacy at Ho Chi Minh City.

  • Specialist Level I in Dermatology – University of Medicine and Pharmacy at Ho Chi Minh City.

  • Specialist Level II in Dermatology (Senior Consultant Level) – University of Medicine and Pharmacy at Ho Chi Minh City.

Continuous Medical Education (CME) & Certifications:
  • Certification: Laser, Radiofrequency (RF), and High-Intensity Focused Ultrasound (HIFU) in Aesthetic Dermatology (UMP HCMC).

  • Certification: Specialized Dermal Filler Injections in Aesthetic Medicine (UMP HCMC).

  • Certification: Advanced Clinical Practice of Botulinum Toxin Injections (UMP HCMC).

  • Certification: Medical Thread Lifting Techniques (UMP HCMC).

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